Make active in a child of located in

biolink-model.yaml

@@ -2739,10 +2739,10 @@ slots:
     range: gene
 
   active in:
+    is_a: located in
     description: >-
       Holds between a gene or gene product and a cellular component in which it carries out its
       molecular function.
-    is_a: related to at instance level
     domain: gene or gene product
     range: cellular component
     annotations:
@@ -2751,7 +2751,7 @@ slots:
       - RO:0002432
 
   has active component:
-    is_a: related to at instance level
+    is_a: location of
     inverse: active in
     domain: cellular component
     range: gene or gene product

tests/test_canonical_annotation.py

@@ -41,6 +41,12 @@ def test_protein_accepts_ncit_prefix(load_biolink_model):
     assert protein is not None
     assert "NCIT" in protein.id_prefixes
 
+def test_active_in_is_a_located_in(load_biolink_model):
+    """Ensure active in is modeled as a specialization of located in."""
+    model = SchemaView(load_biolink_model)
+
+    assert model.get_slot("active in").is_a == "located in"
+    assert model.get_slot("has active component").is_a == "location of"
 
 def test_macromolecular_complex_accepts_iuphar_target_prefix(load_biolink_model):
     """Ensure GtoPdb target identifiers are valid for macromolecular complexes."""
@@ -52,4 +58,4 @@ def test_macromolecular_complex_accepts_iuphar_target_prefix(load_biolink_model)
     assert (
         model.schema.prefixes["IUPHARobj"].prefix_reference
         == "https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId="
-    )
+    )